2 DOSAGE AND ADMINISTRATION

Do not take Revatio or Viagra if you are allergic to sildenafil or any ingredients contained in this drug.

Related/similar drugs

Generic for Viagra ® contains Sildenafil, a doctor-trusted ingredient that is effective for treating ED. Read more about the cost of generic Viagra® and brand-name Viagra® on our blog. The Generic for Viagra ® is called Sildenafil Citrate. This means that the generic form of Viagra ® will have the same therapeutic effect, but at a lower cost Yes, generic forms of Viagra® are just as safe as Viagra®. Both Viagra® and generic for Viagra® were approved by the Food and Drug Administration (FDA) to treat ED and millions of men have used Viagra® or the generic for Viagra® to treat their erectile dysfunction.

5.8 Effects on Bleeding

Generic medications do not compromise the safety of a medication. The cost is lower than brand name medication for many reasons, most notably because the brand name medication is no longer legally protected against competition from other manufacturers. Generic for Viagra® may not be safe for men with some pre-existing conditions or who are taking medications that may interact with the drug. If you have (or have ever had) heart problems (such as a heart attack), heart disease, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, heart failure, heart surgery, pulmonary hypertension including pulmonary arterial hypertension, stroke, low blood pressure, high blood pressure, a deformed penis shape (Peyronie’s Disease), priapism (an erection that lasts for more than 4 hours), sickle cell anemia, multiple myeloma, leukemia, retinitis pigmentosa (a rare genetic eye disease), severe vision loss (such as NAION), bleeding problems, stomach ulcers, liver problems or kidney problems (such as kidney dialysis), you may be at higher risk for adverse effects. If you have any of these health conditions, or any other health condition, tell your healthcare provider. In case of overdose, get medical help or contact a Poison Control Center immediately Soluble guanylate cyclase (sGC) stimulators (e.g., riociguat); concomitant use can cause hypotension Co-administration with nitrates (either regularly and/or intermittently) and nitric oxide donors Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure. See "What Are Side Effects Associated with Using Sildenafil?" Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi See "What Are Side Effects Associated with Using Sildenafil?” Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure Use with caution in patients with anatomic deformation of penis (e.g., angulation, cavernosal fibrosis, or Peyronie disease), conditions potentially predisposing to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia), cardiovascular disease, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, multidrug antihypertensive regimens, retinitis pigmentosa, concomitant use of CYP3A4 inhibitors Pulmonary vasodilators may significantly worsen cardiovascular status of patients with pulmonary veno-occlusive disease Patients taking alpha blocker should be stabilized before starting phosphodiesterase (PDE)-5 inhibitor, which should be initiated at lowest dose; if patient is already taking optimized dose of PDE-5 inhibitor, alpha blocker should be initiated at lowest dose to avoid hypotension Not to be taken with other PDE-5 inhibitors Sudden decrease or loss of hearing, which may be accompanied by tinnitus and dizziness Viagra: Patients should stop sildenafil and seek medical care if a sudden loss of vision occurs in 1 or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION); use with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION; patients with a ”crowded” optic disc may also be at an increased risk of NAION Viagra: Potential for cardiac risk with sexual activity in patients with preexisting cardiovascular disease; therefore, treatment for erectile dysfunction generally should not be instituted in men for whom sexual activity is inadvisable because of their underlying cardiovascular status May cause dose-related impairment of color discrimination; use caution in patients with retinitis pigmentosa Evaluate underlying causes of erectile dysfunction or BPH before initiating therapy Revatio: In small, prematurely terminated study of patients with PAH secondary to sickle-cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo; effectiveness of sildenafil in PAH secondary to sickle-cell anemia has not been established; the clinical relevance to men treated for erectile dysfunction with sildenafil is not known Revatio: Not for use in children with PAH; increased mortality with increasing doses (hazard ratio 3.5) was observed in randomized, double-blind, placebo-controlled clinical trial of 234 children (1-17 years) with PAH who had mild-to-moderate symptoms at baseline Revatio: Epistaxis occurred in 13% of patients with PAH secondary to connective tissue disease (e.g., scleroderma); this effect was not seen in idiopathic PAH; incidence was also higher in those receiving concomitant PO vitamin K antagonist therapy (9%) than in those not receiving such therapy (2%) Sildenafil may be acceptable for use during pregnancy Either animal studies show no risk but human studies are not available, or animal studies showed minor risks and human studies were done and showed no risk It is unknown whether sildenafil is distributed into breast milk. Sildenafil tablet is a prescription medicine used to treat erectile dysfunction (ED).

• The societal impact of sildenafil has been profound since its introduction.
• It helped destigmatize the discussion and treatment of erectile dysfunction.
• It spawned a multi-billion dollar market for sexual health pharmaceuticals.
• The "Viagra" brand name became one of the most recognized in the world.
• It led to increased research and development in urology and sexual medicine.
• It also raised important questions about medicalization and lifestyle drugs.
• Direct-to-consumer advertising for ED treatments became widespread.
• It prompted debates about insurance coverage for quality-of-life medications.
• The success of sildenafil accelerated research into other PDE5 inhibitors.
• It highlighted the importance of serendipity in drug discovery.
• Its impact extends beyond medicine into cultural and social spheres.

Sildenafil tablets help a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated).

Sildenafil tablets are not for use in women or children.

Warnings & Precautions

Sildenafil tablets does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS. Please click here for more Important Risk Information Do not take Sildenafil tablets more than one time each day. If you are concerned that you are having side effects related to the medication, please consult your doctor. Please click here for full Prescribing Information and Patient Information. Generic for Viagra ® contains Sildenafil, a doctor-trusted ingredient that is effective for buy sildenafil citrate online canada treating ED, which means that it is just as effective for the treatment of erectile dysfunction as the original ED medication.

Pulmonary Arterial Hypertension

Generic Viagra® is a PDE5 (phosphodiesterase type 5) inhibitor, which works by blocking the PDE5 enzyme, which in turn temporarily relaxes smooth muscle and improves blood flow to the penis during sexual stimulation. While Viagra® is easily recognizable as the “little blue pill,” the generic for Viagra® comes in many different colors and shapes. Authentic pills may be white or blue, round or diamond, etc. The cost of a generic for Viagra® tablet varies based on the strength of the dose of sildenafil it contains, but generally costs anywhere from about $4 to $10 per dose, compared to $50 to $70 per dose for brand-name Viagra®. Through Hims, generic for Viagra® costs 95% less than branded Viagra®. It is not known if Sildenafil tablets are safe and effective in women or children under 18 years of age.

• Comparing 20mg sildenafil to other PDE5 inhibitors highlights differences.
• Tadalafil (Cialis) has a longer duration of action (up to 36 hours).
• Vardenafil (Levitra) has a similar duration to sildenafil but may be less affected by food.
• Avanafil (Stendra) has a faster onset of action (15-30 minutes).
• The choice of drug depends on individual patient needs and response.
• Tadalafil is also approved for daily use at a lower dose (2.5mg, 5mg).
• Side effect profiles are similar but can vary in frequency between individuals.
• Cost and insurance coverage often play a significant role in the choice.
• Some patients may respond better to one medication over another.
• A doctor can help determine the most appropriate medication and dose.
• It may take trial and error to find the optimal treatment.

Depending on your needs, your doctor will prescribe either a dose of 25 mg, 50 mg, or 100 mg. Take Sildenafil tablets exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Sildenafil tablets to take and when to take it. Take Sildenafil tablets about 1 hour before sexual activity. You may take Sildenafil tablets between 30 minutes to 4 hours before sexual activity if needed. Sildenafil tablets can be taken with or without food. If you take Sildenafil tablets after a high fat meal (such as a cheeseburger and french fries), Sildenafil tablets may take a little longer to start working. Sildenafil tablets can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines.

Usual Pediatric Dose for Pulmonary Hypertension

6.1 Clinical Trials Experience

Do not take Sildenafil tablets if you take any other medicines called “nitrates.” Nitrates are used to treat chest pain (angina). Do not take Sildenafil tablets if you take medicines called guanylate cyclase stimulators such as riociguat. Please click here for more Important Risk Information. Tell all your healthcare providers that you take Sildenafil tablets.

5. Warnings and Precautions

Clinical monitoring

If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took Sildenafil tablets. Sildenafil tablets does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS. Please click here for more Important Risk Information Do not take Sildenafil tablets more than one time each day.

8.7 Patients with Renal Impairment

Take Sildenafil tablets about 1 hour before sexual activity. You may take Sildenafil tablets between 30 minutes to 4 hours before sexual activity if needed. Sildenafil tablets can be taken with or without food. If you take Sildenafil tablets after a high fat meal (such as a cheeseburger and french fries), Sildenafil tablets may take a little longer to start working. Sildenafil tablets can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines.

Who should not take sildenafil?

Do not take Sildenafil tablets if you take any other medicines called “nitrates.” Nitrates are used to treat chest pain (angina). Do not take Sildenafil tablets if you take medicines called guanylate cyclase stimulators such as riociguat. Please click here for more Important Risk Information. Tell all your healthcare providers that you take Sildenafil tablets. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took Sildenafil tablets. If you are concerned that you are having side effects related to the medication, please consult your doctor. Please click here for full Prescribing Information and Patient Information. Generic for Viagra ® contains Sildenafil, a doctor-trusted ingredient that is effective for buy sildenafil citrate online canada treating ED, which means that it is just as effective for the treatment of erectile dysfunction as the original ED medication. Generic Viagra® is a PDE5 (phosphodiesterase type 5) inhibitor, which works by blocking the PDE5 enzyme, which in turn temporarily relaxes smooth muscle and improves blood flow to the penis during sexual stimulation.

Overdose/Missed Dose

Do not take Revatio or Viagra if you are allergic to sildenafil or any ingredients contained in this drug. In case of overdose, get medical help or contact a Poison Control Center immediately Soluble guanylate cyclase (sGC) stimulators (e.g., riociguat); concomitant use can cause hypotension Co-administration with nitrates (either regularly and/or intermittently) and nitric oxide donors Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure. See "What Are Side Effects Associated with Using Sildenafil?" Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi See "What Are Side Effects Associated with Using Sildenafil?” Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure Use with caution in patients with anatomic deformation of penis (e.g., angulation, cavernosal fibrosis, or Peyronie disease), conditions potentially predisposing to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia), cardiovascular disease, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, multidrug antihypertensive regimens, retinitis pigmentosa, concomitant use of CYP3A4 inhibitors Pulmonary vasodilators may significantly worsen cardiovascular status of patients with pulmonary veno-occlusive disease Patients taking alpha blocker should be stabilized before starting phosphodiesterase (PDE)-5 inhibitor, which should be initiated at lowest dose; if patient is already taking optimized dose of PDE-5 inhibitor, alpha blocker should be initiated at lowest dose to avoid hypotension Not to be taken with other PDE-5 inhibitors Sudden decrease or loss of hearing, which may be accompanied by tinnitus and dizziness Viagra: Patients should stop sildenafil and seek medical care if a sudden loss of vision occurs in 1 or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION); use with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION; patients with a ”crowded” optic disc may also be at an increased risk of NAION Viagra: Potential for cardiac risk with sexual activity in patients with preexisting cardiovascular disease; therefore, treatment for erectile dysfunction generally should not be instituted in men for whom sexual activity is inadvisable because of their underlying cardiovascular status May cause dose-related impairment of color discrimination; use caution in patients with retinitis pigmentosa Evaluate underlying causes of erectile dysfunction or BPH before initiating therapy Revatio: In small, prematurely terminated study of patients with PAH secondary to sickle-cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo; effectiveness of sildenafil in PAH secondary to sickle-cell anemia has not been established; the clinical relevance to men treated for erectile dysfunction with sildenafil is not known Revatio: Not for use in children with PAH; increased mortality with increasing doses (hazard ratio 3.5) was observed in randomized, double-blind, placebo-controlled clinical trial of 234 children (1-17 years) with PAH who had mild-to-moderate symptoms at baseline Revatio: Epistaxis occurred in 13% of patients with PAH secondary to connective tissue disease (e.g., scleroderma); this effect was not seen in idiopathic PAH; incidence was also higher in those receiving concomitant PO vitamin K antagonist therapy (9%) than in those not receiving such therapy (2%) Sildenafil may be acceptable for use during pregnancy Either animal studies show no risk but human studies are not available, or animal studies showed minor risks and human studies were done and showed no risk It is unknown whether sildenafil is distributed into breast milk. Sildenafil tablet is a prescription medicine used to treat erectile dysfunction (ED). Sildenafil tablets help a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated).

13.1 Carcinogenesis & Mutagenesis & Impairment of Fertility

Sildenafil tablets are not for use in women or children. It is not known if Sildenafil tablets are safe and effective in women or children under 18 years of age. Depending on your needs, your doctor will prescribe either a dose of 25 mg, 50 mg, or 100 mg. Take Sildenafil tablets exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Sildenafil tablets to take and when to take it. While Viagra® is easily recognizable as the “little blue pill,” the generic for Viagra® comes in many different colors and shapes. Authentic pills may be white or blue, round or diamond, etc. The cost of a generic for Viagra® tablet varies based on the strength of the dose of sildenafil it contains, but generally costs anywhere from about $4 to $10 per dose, compared to $50 to $70 per dose for brand-name Viagra®. Through Hims, generic for Viagra® costs 95% less than branded Viagra®. Generic for Viagra ® contains Sildenafil, a doctor-trusted ingredient that is effective for treating ED. Read more about the cost of generic Viagra® and brand-name Viagra® on our blog. The Generic for Viagra ® is called Sildenafil Citrate. This means that the generic form of Viagra ® will have the same therapeutic effect, but at a lower cost Yes, generic forms of Viagra® are just as safe as Viagra®. Both Viagra® and generic for Viagra® were approved by the Food and Drug Administration (FDA) to treat ED and millions of men have used Viagra® or the generic for Viagra® to treat their erectile dysfunction. Generic medications do not compromise the safety of a medication. The cost is lower than brand name medication for many reasons, most notably because the brand name medication is no longer legally protected against competition from other manufacturers. Generic for Viagra® may not be safe for men with some pre-existing conditions or who are taking medications that may interact with the drug.

If you have (or have ever had) heart problems (such as a heart attack), heart disease, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, heart failure, heart surgery, pulmonary hypertension including pulmonary arterial hypertension, stroke, low blood pressure, high blood pressure, a deformed penis shape (Peyronie’s Disease), priapism (an erection that lasts for more than 4 hours), sickle cell anemia, multiple myeloma, leukemia, retinitis pigmentosa (a rare genetic eye disease), severe vision loss (such as NAION), bleeding problems, stomach ulcers, liver problems or kidney problems (such as kidney dialysis), you may be at higher risk for adverse effects.

8.6 Patients with Hepatic Impairment

Your provider should be aware of all medical conditions, prescription drugs and over-the-counter meds that you are taking. Multiple companies make generic for Viagra®, including Teva Pharmaceuticals and Greenstone, a subsidiary of Pfizer Inc. Take sildenafil (generic for Viagra®) about one hour before sexual activity, as it takes about 30 minutes to an hour to begin working. Check out our guide on how to take Viagra® for best results. If you are currently taking any over-the-counter, recreational or prescription drugs or supplements, tell your healthcare provider.

What are the most common side effects of sildenafil?

Some medications, like nitroglycerin (nitrates), isosorbide dinitrate, riociguat, ritonavir, itraconazole, ketoconazole, alpha blockers and “poppers”, have well-documented drug interactions with sildenafil and could cause serious side effects. If you are currently taking a PDE5 inhibitor, like Revatio for pulmonary arterial hypertension, talk to your doctor about adjusting your dosage. There are also some rare, serious side effects of sildenafil, namely an allergic reaction, loss of vision/hearing, or priapism, an erection lasting for more than four hours. If you have any of these health conditions, or any other health condition, tell your healthcare provider.

• Sildenafil interacts with nitrate medications, causing dangerous drops in blood pressure.
• Store sildenafil in a cool, dry place away from children.
• 20mg is often recommended as a starting dose for ED treatment.
• Food, especially high-fat meals, can delay its onset of action.
• Regular use can improve erectile response over time if prescribed.

Your provider should be aware of all medical conditions, prescription drugs and over-the-counter meds that you are taking. Multiple companies make generic for Viagra®, including Teva Pharmaceuticals and Greenstone, a subsidiary of Pfizer Inc. Take sildenafil (generic for Viagra®) about one hour before sexual activity, as it takes about 30 minutes to an hour to begin working. Check out our guide on how to take Viagra® for best results. If you are currently taking any over-the-counter, recreational or prescription drugs or supplements, tell your healthcare provider. Some medications, like nitroglycerin (nitrates), isosorbide dinitrate, riociguat, ritonavir, itraconazole, ketoconazole, alpha blockers and “poppers”, have well-documented drug interactions with sildenafil and could cause serious side effects. If you are currently taking a PDE5 inhibitor, like Revatio for pulmonary arterial hypertension, talk to your doctor about adjusting your dosage. There are also some rare, serious side effects of sildenafil, namely an allergic reaction, loss of vision/hearing, or priapism, an erection lasting for more than four hours.